Cell Cycle Checkpoints Biology Diagrams Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next. They are important to signal cell stress and DNA lesions and to stop cell cycle progression when severe problems occur. Recent work suggests, however, that the cell cycle control machinery responds in more subtle and sophisticated ways when cells are faced with naturally occurring challenges, such as
Here, I discuss the current evidence for checkpoint adaptation in human cells and possible mechanisms and implications of this phenomenon.
The Hammer and the Dance of Cell Cycle Control Biology Diagrams
MCPH1 function, a centrosomal protein that modulates chromosome condensation and cell cycle progression, is required to confer cellular adaptation to the DC, which means spontaneous checkpoint
Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mech โฆ
Cell cycle regulation by checkpoints Biology Diagrams
Most cells that undergo G2/M-phase checkpoint adaptation (hereafter called checkpoint adaptation) after treatment with a genotoxic agent die in mitosis. However, a small number of those cells survive, and are likely to have extensively altered genomes due to the processes of repair and adaptation [6, 8].
